Aquagenic Palmar Wrinkling Induced by Combined Use of Salazopyrin and Indomethacin
نویسندگان
چکیده
Aquagenic palmar wrinkling (APW) is an uncommon dermatological condition, which manifests as asymptomatic or tender palmar papules and may cause discomfort and manual functional limitations during its flares. Despite some studies implying a relationship between cystic fibrosis (CF) and APW, there are also reports of APW cases without an accompanying CF. In this report we describe a 19-year-old ankylosing spondylitis patient, who developed APW lesions after the start of combined salazopyrin and indomethacin treatment. His palmar lesions were resistant to topical corticosteroid and aluminium hydroxide therapy and disappeared only after stopping the anti-inflammatory drugs. With this report, we aim to highlight and address this underrecognized dermatological condition and possible role of aquaporins in its pathogenesis.
منابع مشابه
Aquagenic wrinkling of the palms.
A healthy 23-year-old woman presented with a six-month history of white lesions on her palms. The lesions would swell after being in water for 15 minutes and return to baseline 10–15 minutes after drying. The patient did not take medications except for oral contraceptive pills, and she was not aware of a family history of similar complaints. Physical examination showed white, slightly transluce...
متن کاملAquagenic wrinkling of the palms: A case report and literature review.
Aquagenic wrinkling of the palms (AWP) is a condition that results in pain and edema of the hands after exposure to water. We describe a 32-year-old woman who presented with a several-year history of AWP. She was unable to tolerate a 20 percent aluminum chloride solution because of irritation, but a gel formulation of 15 percent aluminum chloride controlled her symptoms without side effects.
متن کاملGabapentin-induced aquagenic wrinkling of the palms.
Aquagenic keratoderma (AK) or aquagenic wrinklingis a rare palmoplantar skin disease. It is sporadic orhereditary condition. It appears in childhood or youngadulthood and it is seen as multiple asymptomaticsmall shiny papules on the peripheral margin ofpalms and/or soles after submersion in water. Thepathogenesis and etiology of ASA remains unclear.Drugs sometimes trigger AK. Herein, we present...
متن کاملAquagenic keratoderma associated with a mutation of the cystic fibrosis gene.
Reported for the first time in 1996, aquagenic keratoderma is a rare condition which is characterized by edematous flat-topped papules appearing on palmar skin after water immersion. Multiple anecdotal associations have been described but, recently, the association with cystic fibrosis gene mutations (CFTR) has been highlighted. The authors describe an 18 year-old female, with one-month complai...
متن کاملDrug-associated aquagenic wrinkling of the palms in an atopic male patient.
To cite: Glatz M, Muellegger RR. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014203929 DESCRIPTION A 19-year-old male patient presented with a 2-week history of intensely pruritic white papules and mild wrinkling of the skin of both his palms (figure 1). Other body sites were unaffected. The skin lesions developed during showering and completely resolved by i...
متن کامل